In 1996, 56 volunteers took part in a study to test a new painkiller called Trivaricaine. On each subject, one index finger was covered in the new painkiller while the other remained untouched. Then both were squeezed in painful clamps. The subjects reported that the treated finger hurt less than the untreated one. This shouldn’t be surprising, except Trivariate wasn’t actually a painkiller, just a fake concoction with no pain-easing properties at all. What made the students so sured this dummy drug had worked? The answer lies in the PLACEBO EFFECT, an unexplained phenomenon wherein drugs, treatments, and therapists that aren’t supposed to have an effect, and are often fake, miraculously make people feel better.

Doctors have used the term placebo since the 1700s when they realized the power of fake drugs to improve people’s symptoms. These were administered when proper drugs were not available, or if some one imagined they were ill. In Fact the word placebo means “I shall please” in Latin, hinting at a history of placating troubled patients.

Image result for placebo effect

Placebo had to mimic the real treatments in order to be convincing, so they took the form of sugar pills, water filled injections, and even sham surgeries. Soon, doctors realized that duping people in this way had another use : in clinical trials. By the 1950s, researchers were using placebos as a standard tool to test new treatments.

Nowadays, it’s less common to use placebos this way because of ethical concerns. If it’s possible to compare a new drug against an older version, or another existing drug, that’s preferable to simply giving someone no treatment at all, especially if they have a serious ailment. In these cases, placebos are often used as a control to fine-tune the trial so that the effects of new versus the old or alternative drugs can be preciously compared. But of course, we know the placebos exert their own influence, too.

Thanks to the placebo effect patients have experienced relief from a range of ailments, including heart problems, asthma, and severe pain, even though all they’d received was a fake drugs or sham surgery. We’re still trying to understand how. Some believe that instead of being real, the placebo effect is merely confused with other  factors, like patients trying to please doctors by falsely reporting improvements.

Image result for placebo effect

On the other hand, researchers think that if a person believes a fake treatment is real, their expectations recover actually do trigger physiological factors that improve their symptoms. Placebos seem to be capable of causing measurable change in blood pressure, heart rate, and the release of pain-reducing chemicals, like endorphins. That explains why subjects in pain studies often say placebos ease their discomfort. Placebos may even reduce levels of stress hormones, like adrenaline, which can slow the harmful effect of an ailment.

So shouldn’t we celebrate the placebo’s bizarre benefits? Not necessarily. If somebody believes a fake treatment has cure them, they miss out on drugs and therapies that are proven to work. Plus, the positive effects may fade over time, and often do.

Placebo also cloud clinical results, making scientists even more motivated to discover how they wield such power over us. Despite everything we know about the human body, there are still some strange and enduring mysteries, like the placebo effect.

Source : TED-Ed


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